WHAT is the IVB
The IVB is a revolutionary regenerative medicine paradigm and a novel approach to engineer functional tissue IN VIVO, within the patients' own body, using his or her own cells, for autologous (self) transplantation.
The first example of the successful implementation of the IVB approach was in the engineering of autologous Bone by injecting calcium Alginate in a sub-periosteal location [1,2]. This is the first and only example of bone tissue engineering without implantation of cells and/or growth factor augmentation to date. This engineered ectopic bone mass was then successfully transplanted in a bone defect within the same animal subject. The extension of the IVB paradigm to engineering autologous Hyaline Cartilage was also recently demonstrated [3]. Since the formation of cartilage occurs in a relative short period of less than two weeks and cartilage can remodel into bone, this approach might provide some advantages in treatment of both cartilage and bone loss. The IVB is currently being implemented in humans.
Know more about how the IVB is implemented and works CLICK HERE
References:
[1] The In Vivo Engineering of Organs: the Bone Bioreactor, Proceedings of the National Academy of Sciences, USA (2005) http://www.pnas.org/content/102/32/11450
[2] Technique uses body as the “bioreactor” to grown new bone, Robert F. Service, Science 29 July 2005: Vol. 309 no. 5735 p. 683, http://www.sciencemag.org/content/309/5735/683.1, DOI: 10.1126/science.309.5735.683a
[3] Autologous Engineering of Cartilage, Proceedings of the National Academy of Sciences, USA (2010) http://www.pnas.org/content/107/8/3418.abstract
The first example of the successful implementation of the IVB approach was in the engineering of autologous Bone by injecting calcium Alginate in a sub-periosteal location [1,2]. This is the first and only example of bone tissue engineering without implantation of cells and/or growth factor augmentation to date. This engineered ectopic bone mass was then successfully transplanted in a bone defect within the same animal subject. The extension of the IVB paradigm to engineering autologous Hyaline Cartilage was also recently demonstrated [3]. Since the formation of cartilage occurs in a relative short period of less than two weeks and cartilage can remodel into bone, this approach might provide some advantages in treatment of both cartilage and bone loss. The IVB is currently being implemented in humans.
Know more about how the IVB is implemented and works CLICK HERE
References:
[1] The In Vivo Engineering of Organs: the Bone Bioreactor, Proceedings of the National Academy of Sciences, USA (2005) http://www.pnas.org/content/102/32/11450
[2] Technique uses body as the “bioreactor” to grown new bone, Robert F. Service, Science 29 July 2005: Vol. 309 no. 5735 p. 683, http://www.sciencemag.org/content/309/5735/683.1, DOI: 10.1126/science.309.5735.683a
[3] Autologous Engineering of Cartilage, Proceedings of the National Academy of Sciences, USA (2010) http://www.pnas.org/content/107/8/3418.abstract